Another interesting study titled "antiestrogen tamoxifen in the treatment of Recurrent Benign Cystic Mesothelioma" Gerard S. Letteriea, and Joseph L. Yonb -
. Gynecologic Oncology, Volume 70, Issue 1, July 1998 Page 131-133 Here is an excerpt: "Abstract - Benign cystic mesothelioma is a tumor characteristically found in women during reproductive years, these tumors are rarely found after castration. Or menopause, suggesting some degree of hormonal sensitivity. such aspects of the tumor suggest a potential role for antiestrogens as medical management and an alternative to radical surgery. We treated 19-year-old woman with symptomatic pelvic mass secondary recurring benign cystic mesothelioma 2 years after radical surgery with the antiestrogen tamoxifen. initial reduction in volume growth and arrests after stabilization in size and resolution of symptoms. therapy was continued for 18 months without a change in the volume of cystic structures. the patient continues to be asymptomatic. Periodic surveillance with quantitative digital radiography for bone density showed no change in bone mineral density. serum tests of liver function tests are normal in throughout the treatment. this case suggests that antiestrogens may have a role in managing health care of these rare tumors are estrogen-dependent neoplasms. an initial reduction in size and arrest the growth further suggest extreme sensitivity of this tumor to manipulation of hormonal milieu. antiestrogen tamoxifen therapy in this setting can provide an opportunity for long-term medical management in case of symptomatic recurrent cystic mesotheliomas ."
Another interesting study entitled, "Expression profile of telomerase subunits in human pleural mesothelioma" Karl Dhaene Jan Wauters, Barbara Weyn, Jean-Pierre Timmermans, Eric Van Marck - Journal of Pathology, Volume 190, Number 1, page 80 to 85, in January 2000 Here's an excerpt: "Abstract - Using the TRAP test, telomerase activity was previously detected in more than 90% of human pleural mesotheliomas (MMS), but not in mesothelial cell cultures (MCC)., suggesting that telomerase reactivation occurs during multi mesothelioma-step carcinogenesis. This study determines the expression of telomerase RNA template (hTERC), telomerase associated protein (hTEP1) and telomerase catalytic subunit (hTERT), in 16 pleural MMS and 4-mm-derived cell lines, two pleural solitary fibrous tumors and six MCC. Reverse transcription-polymerase chain reaction analysis showed that hTERT mRNA expression parallels activity status documented by TRAP assay, whereas hTERC hTEP1 and mRNA are normally expressed in all malignant and non-malignant serosal cells and tissues. Three Alternatively connected hTERT transcripts were detected in all telomerase-positive samples, not the variant could be detected in MCC. hTERT protein detection with a commercially available antibody was not successful. These results indicate that hTERT expression rate of the restriction of human telomerase activity and the re-activation, rather than up-regulation , of hTERT expression may play a key role in MM carcinogenesis. While waiting for a suitable anti-hTERT antibody, and the results provide information for the hTERT mRNA-specific in situ probes to study telomerase in archive pre-malignant lesions, serosal ."
We all owe debt of gratitude to these fine researchers. If you find any of these statements interesting, please read the study in its entirety.
